Based on our experience, if the protease test highlights EPA in the examined wound, a clinician could consider applying dressings that might reduce protease activity in wound. The lesion should be re-evaluated after 2 or 4 weeks of treatment. If protease activity remains high,the clinician should exclude the presence of infection and eventually continue protease-modulating therapy. If protease levels are normal, the wound bed is in the best condition to allow a physiological healing process.Fig 1 is suggested as a guide for clinicians,when an ulcer does not heal after correctable factors(e.g., vascular disease, neuropathy, infection,metabolic disorder) have been addressed.