Results: The results of this study indicate that from the experts’ viewpoint “Perceived Tech-nical Competence” is the most important factor in the Human dimension. In the Technologydimension, the experts agree that the “Relative Advantage” is more important in relationto the other factors. In the Organization dimension, “Hospital Size” is considered moreimportant rather than others. And, in the Environment dimension, according to the expertsjudgment, “Government Policy” is the most important factor. The results of ANP survey fromexperts also reveal that the experts in the HIS field believed that these factors should notbe overlooked by managers of hospitals and the adoption of HIS is more related to moreconsideration of these factors. In addition, from the results, it is found that the experts aremore concerned about Environment and Technology for the adoption HIS.Conclusions: The findings of this study make a novel contribution in the context of healthcareindustry that is to improve the decision process of innovation in adoption stage and to helpenhance more the diffusion of IS in the hospital setting, which by doing so, can provideplenty of profits to the patient community and the hospitals.