In conclusion, this study is the first investigation to evaluate theantioxidant, anti-inflammatory, anti-apoptotic activity, and neu-roprotective effects of GLPS in a SCI model in rats; GLPS representsthe main bioactive compound of the traditionally valued G. lucidumfungus. GLPS treatment improves early functional and biochemicalresults as much as MP and yields better ultrastructural findingsand histomorphological results than MP. Although the results ofthe present study have provided some interesting data confirmingthe useful effect of GLPS after SCI, pathways, which are activatedthrough the GLPS treatment, must be revealed in future studies inorder to explain the exact mechanism underlying the neuropro-tective activity.