That being said at present there is no strong research proving that any of the babies conceived by ICSI have developed impairments in their cognitive and motor skills, but there is an indication of a greater risk of physical abnormalities. An international investigation into ICSI babies found that 4.2% had a major disability, most of these around male genitals. That 4.2% is thrice the number of children with similar malformations who were conceived naturally. This study also showed that a higher percentage of ICSI and IVF children suffered from a significant illness during their childhood.