the rate-limiting enzyme in
the synthesis of glycogen in response to insulin (Embi et al.
1980). Although GSK3 is constitutively active in cells, it is
inactivated in response to insulin stimulation of glycogen
synthesis in muscles (Wang et al. 2009). The aim of the
present study was to investigate the involvement of GSK3,
a component of insulin biosignaling in the hypoglycemic
effects of the active fractions from G. procumbens by
examining the phosporylation state of GSK3 in the liver
of normal and STZ-induced diabetic rats treated with the
fractions.