the M-values showed no correlation with either LBGI C
or Hypo Time obtained by CGM, but was correlated with
HBGI C . The M-value is an index of the degree of divergence
from the optimal blood glucose level, which in this study
was 120 mg/dL, being the mean of values obtained by
logarithmic transformation of successive blood glucose levels
[13]. One problem is that the M-value changes with the timing
and number of blood glucose measurements by SMBG.
In clinical practice, for blood glucose control in patients
with T1DM, not only blood glucose fluctuations but also low
blood glucose levels are problematic, and it is therefore
necessary to evaluate low blood glucose levels. However, it has
been reported that although many blood glucose fluctuation
parameters show correlations with blood glucose fluctuation
within the hyperglycemic range, these show no such correla-
tions within the hypoglycemic range [14]. In addition, LBGI has
been set as an index for specific prediction of hypoglycemia,
but it has been reported to show no correlation within the
hyperglycemic range [14,18]. ADRR, which was put forward as
an index by Kovatchev et al. is calculated from routine SMBG
data over 1 month, collected three to five times per day, and is
considered to be correlated with both future extreme
hyperglycemia and future hypoglycemia [14]. Furthermore,
it has been reported that the results for ADRR obtained by
measurement three times per day on 14 days during a 30-day
period, show no attenuation [14]. In the present study, the
mean number of measurement of blood glucose by SMBG was
4.2 times per day for more than 14 days. Patton et al.
investigated the usefulness of ADRR C and ADRR S for patients
with T1DM aged 2–7 years old, and reported that ADRR C