KU there are four campuses including Bang Khen Campus, Kampangsan Campus, Siracha Campus and Chalermphrakiat Sakhon Nakhon Campus. Recently the University has a plan to establish Supanbury Campus.
Chalermphakiat Sakon Nakhon Province Campus was established in 1996 to commemorate the Golden Jubilee Anniversary of His Majesty King Bhumibol Adulyadej’s Accession to the Throne. The campus occupies the area of 4,488 rai (718 hectares) in Mueang District of Sakon Nakhon Province, Intending to provide much needed development-accelerating academic services and expected to be the center of education for the upper northeastern region of Thailand and the center of agricultural development, while promoting academic support to the Royal Projects and Royal Initiatives, The degree programs at the campus vary in 4 faculties that are Natural Resources and Agro-Industry, Science and Engineering, and Liberal Arts and Management Sciences. Chalemphakiat Sakon Nakhon Province Campus Research and Development institute also was located here.
KU Chalermphrakiat Sakhon Nakhon Campus is The symbol is พระพิรุณทรงนาค and the white bike is the identity of the university. Wich had Associate Professor วิไลศักดิ์ กิ่งคำ as vice chancellor.
Inside of the Chalermphrakiat Sakhon Nakhon Campus there are many buildings total 18buildings.There are four reservoirs in the campus including Sakon nakhon reservoir, Nokhon panom reservoir, Nong kai reservoir and Mukdahan reservoir. Moreover, there are vegetation farm and creature farm. Distant from the university about 5 kilometers has Lotus Park which has many kind of lotuses.