A sequence of eight different phases was included in the experimental observation. During the first phase, phase a (until day 77), ASBR was operated with feeding of just
the selected synthetic substratewithout SMX addition,whereas, during the following three phases, it was operated with semi-continuous feeding of the substrate/SMX mixture: In phase b (days 78–82), the daily SMX dose was maintained at 1 mg/L; the antimicrobial dose was gradually increased to 10 mg/L in phase c (days 82–92), to 25 mg/L in phase d (days 93–101), to 30 mg/L in phase e (days 102–110), to 35 mg/L in phase f (days 110–115), to 40 mg/L in phase g (days 116–127), and finally to 45 mg/L in phase h (days 127–168).
A sequence of eight different phases was included in the experimental observation. During the first phase, phase a (until day 77), ASBR was operated with feeding of justthe selected synthetic substratewithout SMX addition,whereas, during the following three phases, it was operated with semi-continuous feeding of the substrate/SMX mixture: In phase b (days 78–82), the daily SMX dose was maintained at 1 mg/L; the antimicrobial dose was gradually increased to 10 mg/L in phase c (days 82–92), to 25 mg/L in phase d (days 93–101), to 30 mg/L in phase e (days 102–110), to 35 mg/L in phase f (days 110–115), to 40 mg/L in phase g (days 116–127), and finally to 45 mg/L in phase h (days 127–168).
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