Focus. Limit the number of social networks you use to only those most relevant to your work and personal life. For example, in the past I’ve regularly used LinkedIn, Twitter and Facebook for work and Plurk for personal use.
Cull your network. If you really don’t know someone well or at all, don’t feel obligated to friend or follow them. Even though social media plays a large part in my daily work, I still do not approve every friend request. The person has to have some connection to me, either friends or interests in common, and has to display a real profile pic, not an avatar, photo of an inanimate object, or some random starlet.