From the finding that Muller cells are capable of gluconeogenesis, glycogen synthesis, and breakdown and release of glucose, we propose that Muller cells can use lactate from photoreceptors to synthesize glucose, store it as glycogen,
and provide it to neurons of the inner retina when required. The very low expression of pyruvate kinase in Muller cells is consistent with gluconeogenesis being the predominant pathway for glucose metabolism in these cells. An important caveat for this model is that the evidence for Muller cell gluconeogenesis, thus far, comes
From the finding that Muller cells are capable of gluconeogenesis, glycogen synthesis, and breakdown and release of glucose, we propose that Muller cells can use lactate from photoreceptors to synthesize glucose, store it as glycogen,and provide it to neurons of the inner retina when required. The very low expression of pyruvate kinase in Muller cells is consistent with gluconeogenesis being the predominant pathway for glucose metabolism in these cells. An important caveat for this model is that the evidence for Muller cell gluconeogenesis, thus far, comes
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