compounds effective as steriospecific catalysts towards oxidation, reduction, hydrolysis biological activity and other transformations of organic and inorganic chemistry. In organic compounds the presence of -N=C- along with other functional groups form more stable complexes compared to compounds with only -N=C- coordinating moiety. Similarly pyridine derivatives have been of great interest because of their role in natural and synthetic organic chemistry. Many products which contain a pyridine subunit exhibit biological activity such as antimicrobial and antituberculosis activities. So the pyridine containing Schiff bases are expected to have enhanced biological activities. It is well established that the biological activity associated with the hydrazone compound attributed to the presence of the active pharmacophore (-CONH-N-C-). Hence many hydrazone compounds containing this active moiety showed good biological activities according to the literature. In the present work, we have synthesized fifieen Schiff base from nicotino hydrazide with substituted aromatic benzaldehydes afforded title compounds (2a-n) and
evaluated their in vitro antioxidant activity.