In wine, polyphenolic concentrations can be altered by maceration, fermentation techniques, and aging, which influence color and oxidative stability. Few studies have reported copigmentation effects of anthocyanins in actual food systems due to their inherent phytochemical complexity. Due to its high concentrations of isoflavonoids, red clover extracts were evaluated for their potential to serve as an anthocyanin cofactors in muscadine grape juice and wine.