Nutanix recommends that you disable SIOC and SIOC in stats mode on the ESXi hosts, because SIOC in stats mode results in storage unavailability or might cause Stargate to become unresponsive for a brief period of time on AOS versions 4.5, 4.5.0.1, and 4.5.0.2.
By default, the SIOC feature is not enabled, but SIOC in Stats Mode is enabled by default on all the datastores in the ESXi host.
SIOC is an excellent feature, but Nutanix recommends to disable this setting on a Nutanix scale-out architecture, because this setting might cause storage and Stargate unavailability.