Among overweight and obese adults with knee OA, after 18
months, participants in the D+E and D groups had more weight
loss and greater reductions in IL-6 levels than those in the E
group, those in the D group had greater reductions in knee compressive
force than those in the E group, and those in the D+E
group had less knee pain and better function than those in the
D and E groups and improved physical HRQL than those in the
E group.