Dietary sources of fructose include fruit, honey, sucrose, and high-fructose corn syrup, an inexpensive sweetener used in a wide variety of processed foods and beverages. Fructose, second only to glucose as a source of carbohydrate in the modern human diet, can enter the glycolytic pathway by two routes. In the liver, fructose is converted to fructose-1-phosphate by fructokinase: When fructose-1-phosphate enters the glycolytic pathway, it is first split into dihydroxyacetone phosphate (DHAP) and glyceraldehyde by fructose-1-phosphate
aldolase. DHAP is then converted to glyceraldehyde-3-phosphate by triose phosphate isomerase. Glyceraldehyde-3-phosphate is generated from glyceraldehyde and ATP by glyceraldehyde kinase.
Dietary sources of fructose include fruit, honey, sucrose, and high-fructose corn syrup, an inexpensive sweetener used in a wide variety of processed foods and beverages. Fructose, second only to glucose as a source of carbohydrate in the modern human diet, can enter the glycolytic pathway by two routes. In the liver, fructose is converted to fructose-1-phosphate by fructokinase: When fructose-1-phosphate enters the glycolytic pathway, it is first split into dihydroxyacetone phosphate (DHAP) and glyceraldehyde by fructose-1-phosphatealdolase. DHAP is then converted to glyceraldehyde-3-phosphate by triose phosphate isomerase. Glyceraldehyde-3-phosphate is generated from glyceraldehyde and ATP by glyceraldehyde kinase.
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