Diabetes mellitus (DM) is a metabolic disease, characterized by hyperglycemia resulting from insulin action Secretion together with
impaired metabolism of glucose, lipids and protein. The WHO Expert Committee recommended that the important to investigate
the hypoglycemic agents from plant origin, which were used in traditional medicine for the treatment of diabetes mellitus.
Thunbergia fragrans Roxb belong to the family Acanthaceae. The anti-hyperglycemic effect of hydroalcoholic extract of Thunbergia
fragrans Roxb was evaluated in diabetic rats using alloxan monohydrate 150mg/kg for pilot study (4 weeks) so as to assess their
effect in mild (Plasma sugar > 180mg/dl duration 28days) diabetes mellitus. In the pilot study maximum reduction of 33% and 35%
glucose levels was observed in animals receiving 200mg and 400mg/kg per day of hydro alcoholic extract of Thunbergia fragrans
Roxb (HAETF) after 4 weeks of treatment, respectively. The alteration in hepatic glycogen content and hepatic glucokinase,
hexokinase and glucose-6-phosphate levels in diabetic rats were partially restored by hydroalcoholic extract of Thunbergia fragrans
Roxb.
Keywords: Diabetic mellitus, Thunbergia fragrans Roxb, Alloxan monohydrate.