Induction of diabetes in rats
Wistar rats weighing 160 ± 15 g were housed in an animal facility. The animals were acclimatized to the environment (26 ± 5°C, 55 ± 10% relative humidity, and 12 h dark/light cycle) for 1 week prior to experimental use. The rats were fed with a standard laboratory diet (Amruth feeds Pvt. Ltd, Bangalore) and water ad libitum. Ethical clearance was obtained from Institutional Animal Ethics Committee of Animal Research (IAEC approval number: UOM/IAEC/09/2012) at DOS in Zoology, University of Mysore, and experiments were carried out as per the guidelines of the committee.
The animals were divided into 4 groups and each group consisted of 5 rats:
Group 1: Control- normal untreated rats (citrate buffer injected)
Group 2: Diabetic- STZ diabetic rats
Group 3: BOvG800- STZ rats treated with BOvG (800 mg/kg body weight)
Group 4: Glibenclamide- STZ rats treated with glibenclamide (1 mg/kg body weight)
Overnight fasted animals were made diabetic by intra-peritoneal injection of freshly prepared streptozotocin in citrate buffer (0.1 M, pH 4.5) at a dose of 47 mg/kg body weight. The control rats were only injected with citrate buffer.
Induction of diabetes in ratsWistar rats weighing 160 ± 15 g were housed in an animal facility. The animals were acclimatized to the environment (26 ± 5°C, 55 ± 10% relative humidity, and 12 h dark/light cycle) for 1 week prior to experimental use. The rats were fed with a standard laboratory diet (Amruth feeds Pvt. Ltd, Bangalore) and water ad libitum. Ethical clearance was obtained from Institutional Animal Ethics Committee of Animal Research (IAEC approval number: UOM/IAEC/09/2012) at DOS in Zoology, University of Mysore, and experiments were carried out as per the guidelines of the committee.The animals were divided into 4 groups and each group consisted of 5 rats:Group 1: Control- normal untreated rats (citrate buffer injected)Group 2: Diabetic- STZ diabetic ratsGroup 3: BOvG800- STZ rats treated with BOvG (800 mg/kg body weight)Group 4: Glibenclamide- STZ rats treated with glibenclamide (1 mg/kg body weight)Overnight fasted animals were made diabetic by intra-peritoneal injection of freshly prepared streptozotocin in citrate buffer (0.1 M, pH 4.5) at a dose of 47 mg/kg body weight. The control rats were only injected with citrate buffer.
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