Hyaluronic acid treatment achieved a reduction in the mean depth of the RA parameter from 120.8 lm to 55.4 lm at 2 weeks (V3) after the first implant, indicating an excellent filling product activity which was still marked for up to 6 months; in particular the percentage reduction in RA corresponded to 51.7% at V3, 46.9% at V4, 42.9% at V5, 35.2% at V6, 16.5% at V7 and 6.5% at V8.