For example, our group has observed that the C. elegans bre mutants with resistance to Cry5B are hyper- sensitive to Cry6A, and combination of Cry5B and Cry6A exhibits obvious synergism (Yu et al., 2014); Peng et al. (2011) have discov- ered that Cry6A shows distinct binding profile with the total pro- tein of RKN than Cry5B.