Treatment
The general principle of treatment of hypopituitarism holds good for the treatment of SS also. The goal of therapy is to replace deficient hormones. Treatment is important not only to correct endocrine abnormalities, but also to reduce mortality due to hypopituitarism.[1] In patients who have both secondary hypothyroidism and hypocortisolism, glucocorticoids should be replaced before the replacement of thyroid hormone. Gonadotropin deficiency and hypogonadism should be treated with a hormone replacement therapy.[1,21] Patients who wish to become pregnant may be directed to the service of fertility for ovulation induction followed by successful pregnancy. For patients with diabetes insipidus, treatment of choice is 1-desamino-8-d-arginine vasopressin or desmopressin (DDAVP).[21] Replacement of GH should be considered in patients with GH deficiency. Dosage of GH needs to be individualized. GH should be started on a low-dose regimen (0.1–0.3 mg/d) and titrated upward by 0.1 mg/d per month with careful monitoring, so as to maintain insulin-like growth factor-1 levels within the age-appropriate range for the patient.[59] These patients may benefit from GH replacement, especially with regard to cardiovascular risk and body composition.