Nowadays, dental caries occurs the most compared to other dental diseases according to the survey of oral health status of the Ministry of Health since 2012 found that dental caries found in all ages. The major cause of eating behavior which cause the bacteria that causes dental caries. One method used for the treatment of tooth decay is to reduce the number of pathogens by using chemicals or drugs. However, the chemicals or drugs have cytotoxicity than compared with biological substances. So this study, Is interested to test in vivo inhibition of pathogens in the oral cavity of crude extract ethanol from early Clausena cambodiana Guill Using the disc diffusion (disc diffusion method) which was shown inhibition bacteria . from this study it can be concluded that The crude extract of the Clausena cambodiana Guill has the ability to inhibit bacteria in the oral cavity.