The highest risk of malaria infection for the traveler in Cambodia is in forested areas. There is little to no transmission of malaria around Angkor Wat, Tonle Sap Lake around Siem Reap, and Phnom Penh. On a typical 2- to 4-day visit that involves exploring the close-in temples during the day and staying in an air-conditioned hotel in Siem Reap at night, malaria risk is minimal. However, mosquito protection measures should still be employed. Travelers planning to visit the more remote temples deeper in the forest, especially in the early morning and evening, should consider malaria chemoprophylaxis. The recommended chemoprophylaxis regimen for Siem Reap Province is atovaquone-proguanil or doxycycline.