The formulation of three phytopharmaceutical products of Andrographispaniculata fractions (AP fraction A and B) containing
diterpene lactones as an active substance were developed and their antimalarial activities against Plasmodium bergheihas been
examined. In vivo antimalarial assay on P. berghei infected mice was carried out by oral administration,twice a dayfor four
consecutive days of the AP fractions product, which were Tablet I : wet granulated formula of AP fraction A; Tablet II : wet
granulated formula of AP fraction B; Tablet III : solid dispersion formula of AP fraction B.. The results revealed that three
phytopharmaceutical products of A.paniculata were inhibited parasite’s growth with inhibition range of 70.15% to 80.35%. There
was no significant difference of antimalarial activities between Tablet II and III, meanwhile there was significant difference
among Tablet I with Tablet II and Tablet III.It was concluded that antimalarial activity depending on raw material form of A.
paniculata active substance.