Renal cell carcinoma (RCC) is traditionally considered to be resistant to conventional low dose radiation
therapy (RT). The emergence of image-guided stereotactic body radiation therapy (SBRT) made it
possible to deliver much higher doses of radiation. Recent clinical trials of SBRT for RCC showed
improvement in local control rates and acceptable toxicity. Here we report a case of inoperable symptomatic
RCC that was managed with SBRT. Strikingly, the presenting symptoms of gross hematuria and
severe anemia were completely resolved following a course of SBRT. Thus, our case report highlights the
potential benefit of this technique for patients with inoperable RCC.