4. Discussion
In the current study, we assessed the effects of omega-3 fatty
acid supplementation on insulin metabolism parameters, lipid
profiles, biomarkers of inflammation and oxidative stress among
patients with DN. We found that omega-3 fatty acid supplementation
for 12 weeks among DN patients had beneficial effects on
serum insulin levels, HOMA-B, QUICKI, serum triglycerides and
VLDL-cholesterol, but it did not influence other subfractions, biomarkers
of inflammation and oxidative stress. To our knowledge,
the current randomized clinical trial is the first indicating the effects
of omega-3 fatty acid administration on markers of insulin
resistance, lipid concentrations, biomarkers of inflammation and
oxidative stress in patients with DN. It must be kept in mind that a
large proportion of the participants (over 2/3) of our study were on
insulin. This condition can limit the potential applicability of the
HOMA model in the current study [22].