The SUN Study is a dynamic cohort of university graduates.
The objectives and methods of the SUN cohort were
reported in detail elsewhere.10 Briefly, beginning in December
1999, a letter of invitation and a questionnaire
were sent to all alumni of the University of Navarra and
other university graduates living in Spain. The baseline
questionnaire gathered information on socio-demographic
variables, lifestyle (including diet and physical activity),
and medical information. Because of the dynamic cohort
design, enrollment of participants is continuously open.
The study protocol was approved by the Institutional Review
Board of the University of Navarra. Response to the
initial questionnaire was considered an informed consent
to participate in the study.