This study evaluated flavonoids extracted from lotus (Nelumbo nuficera Gaertn) on reducing
hyperglycemia and hyperlipidemia in alloxan-induced diabetic mice. flavonoids from lotus(FLL) was
orally administered once a day after 3 days of alloxan -induction at 50 and 200 mg/kg for 28 day, and the
results showed that fasting blood glucose ,serum TC and TG levels were significantly decreased,
whereas serum HDL-c level were increased. The dosage of 200 mg/kg is more effective than that of 50
mg/kg. In addition, FLL did not exhibit any toxic symptoms in the limited toxicity evaluation in male
mice. The above results suggested that FLL could control blood glucose and modulate the metabolism
of glucose and blood lipid. So we conclude that the FLL should be evaluated as a candidate for future
studies on diabetes mellitus