The optimum timing of administration of antibiotic remain nebulous. SCC guidelines suggest that an antimicrobial regimen should be started within one hour of a diagnosis of sepsis. There are, however, no published data that establish a crucial 'time to antibiotic' interval. SSC also recommends that antibiotic be re-evaluated after 48-72 hours to determine the adequacy of the antimicrobials, and to wean those drugs not required(5)