Other problems in the management of TBM include the
challenge of multi-drug resistant disease, to which there is
no easy answer. Theoretically, patients with multi-drug
resistant TBM should be treated according to the drug
resistance profile of the causative organism in each
individual case. The patient, however, may well be moribund
by the time such information becomes available,
though the detection of mutations coding for specific drug
resistance may permit more rapid characterisation of
resistant disease.