Due to the increased urine glucose excretion, the newly
developed sodium–glucose cotransporter-2 inhibitors
for the treatment of diabetes mellitus type 2 are
associated with a very small increased risk of urinary
tract infections (UTIs).
Diabetes mellitus with complications is an independent
predictor of major abnormalities (for instance
hydronephrosis or urolithiasis) on imaging in adult
patients with community-acquired urosepsis.
Group B Streptococcus (GBS) bacteriuria is more
common in pregnant women and associated with
adverse pregnancy complications such as
chorioamnionitis, but treatment implications for clinical
practice are not clear.
Recently, more attention has been drawn to the effects
of antibiotic treatment of ASB or UTI during pregnancy,
which may have long-term consequences for the
neonate such as epilepsy and antibiotic resistance.
More research is needed to further explore and confirm
these findings.
The outdated evidence of the effects of ASB in
combination with the possible negative effects of
antibiotic use to treat ASB during pregnancy warrants
up-to-date research about the ASB screening and
treatment policies during pregnancy.