including hydroperoxides and cyclic peroxides [1]. Enzymatic oxidation ofmembrane phospholipids is mediated by lipoxygenase (LOX) and cycloxygenase (COX). Oxidation of fatty acids derived from membrane phospholipid, such as arachidonic acid, results in the formation of hydroperoxyeicosatetraenoic acid
(HPETE), prostaglandins, thromboxane and leukotrienes. Alternatively, exposure to free radicals, such as hydroxyl radicals, lipid oxyl or peroxyl radicals, singlet oxygen, and peroxynitrite formed from nitrogen oxide, can induce non-enzymatic oxidation of membrane lipids