Chemically Aceclofenac has a carboxylic acid functional group and two chlorine atoms. The design strategy I of this molecule is to exploit the robust carboxylic-acid-amide heterosynthon and amide-chlorine atom heterosynthon when primary
amide containing Nicotinamide is used as co-
former while II strategy is to exploit the carboxylic acid dimer with exofunctional which acts as either a hydrogen bond donor or acceptor. So this chosen API renders itself to be amenable for the synthesis of co-crystals.