3.1. Intravenously transplanted hASC improved motor performances
in the 6-OHDA-induced PD mouse model
To determine the effects of hASC transplantation in PD, hASC
was intravenously transplanted into the tail-vein of the sham
control or 6-OHDA-induced PD mice. Because 6-OHDA, as a specific
catecholaminergic neurotoxin, is not able to cross the blood-brain
barrier, stereotaxical injection of 6-OHDA into the SN is necessary
to cause the nigrostriatal damage.