anti-d immunoglobulin. we as well as others recommend treatment of d-negative women with anti-d immunoglob-ulin after abortion because up to 5 percent of d-negative women will become isoimmunized without it (see chap.29,p.663). in d-negative women with threatened abortion,this practice is controversial,because it lacks evidence-based sup-port(american college of obstetricians and gynecologists,1999:weissman and associates,2002)