The effect of oral feeding of the fruit juice (10 ml of 100% juice) on the
hepatic cytochrome P450 and glutathione S-transferase drug-metabolizing
enzymes was investigated in rats with streptozotocin-induced diabetes. Hepatic
cytochrome P450 contents, ethoxycoumarin-O-deethylase, ethoxyresorufin-O-deethylase,
aniline hydroxylase and aminopyrene N-demethylase
activities were measured in control, diabetic and juice-fed animals. Diabetic
rats exhibited a 50–100% increase in aniline hydroxylase and ethoxyresoru-
fin-O-deethylase activities, which were reversed after being fed the juice. In
addition, a decrease (17–20%) in the activities of N-demethylase and ethoxycoumarin-O-deethylase
was observed in the liver of diabetic rats. Feeding
the juice to the diabetic animals brought the level of N-demethylase close to
that of control animals, while ethoxycoumarin-O-deethylase was further
reduced to 60% of the levels in the control animals (48).