Results
Nephrotoxicity is achieved in patients treated with AmB, though the drug remains one of the most effective solu-tions for the treatment of invasive fungal infections
It should be recalled that urea is derived from the de-struction of proteins and is completely filtered by the glomeruli. Creatinin in blood, a constituent of muscle
protein, is eliminated by the kidneys and is not converted to urea by non-renal factors. Determination of urea and creatinin in the blood reflect the renal function.
Compared to the physiological pH of 7.4 in rats when injected up to 3 mL (maximum volume that can be in-troduced in a rat), there was no change in the blood pH of
the control animals; is kept constant at pH 7.6 ± 0.02.