Therefore, the HS-SPME sample preparation is regarded as a
most suitable analytical method for the volatile nitrosamines. The
typical parameters consisting of salting out effect, extraction
temperature, and extraction time in SPME optimization are investigated
to improve the extraction efficiency. The method is validated with respect to linearity, recovery, and method detection
limit (MDL). This proposed method is successfully demonstrated in
the accurate mass screening, confirmation, and quantification of
n-nitrosamines in cosmetic products.