The authors concluded that hyperoncotic fluids per se do not appear to induce AKI, given that the renal risk is linked to the
type of colloid used. To clarify this controversy, the CRISTAL trial (Colloids Compared to Crystalloids in Fluid Resuscitation of Critically Ill Patients: A Multi-national Randomised Controlled Trial), a large ongoing RCT, is evaluating the efficacy and safety of any type of colloids versus crystalloids for fluid resuscitation in critically ill patients