Independently of the physiological origin of wrinkles, the molecular mechanism involved in the ageing of the skin is directly related to changes in the formation of the triple helix of collagen, the deterioration of the polypeptides of elastin, and disorder in the packing of the skin’s lipid matrix. In other words, skin ageing involves a slow impairment of the cellular functions and thus atrophy of the skin in both the epidermis and the dermis1. However, in recent years, it has been demonstrated that the contractions that appear in the membranous septa of the connective tissue can be responsible for expression lines2. In this regard, favourable results with botulin toxin infiltration led to the development of a new active principle with effects similar to the botox effect, named Argireline®, as an alternative to botulinum toxin.