In a proof-of-concept study, we have shown that it is
possible to establish a biosynthetic pathway de novo in rice
endosperm, enabling the accumulation of provitamin A. Many
variations of this applied technology appear feasible and work
is in progress to optimize the yellow rice lines now in our
hands. In part, this involves the use of different structural
genes and the use of different selectable marker genes. With
the discovery that the lycopene -cyclase is not necessary to
achieve provitamin A synthesis, it may even be possible to
remove the selectable marker from cotransformants by breeding
techniques (Fig. 2). The observation that a regulatory
pathway may be involved calls for in-depth biochemical and
molecular biological analyses, currently being undertaken.
Studies on the bioavailability of the provitamin A, transfer of
the trait into agronomically important varieties, and risk assessments
will be carried out in collaboration with other research
institutes.
In a proof-of-concept study, we have shown that it ispossible to establish a biosynthetic pathway de novo in riceendosperm, enabling the accumulation of provitamin A. Manyvariations of this applied technology appear feasible and workis in progress to optimize the yellow rice lines now in ourhands. In part, this involves the use of different structuralgenes and the use of different selectable marker genes. Withthe discovery that the lycopene -cyclase is not necessary toachieve provitamin A synthesis, it may even be possible toremove the selectable marker from cotransformants by breedingtechniques (Fig. 2). The observation that a regulatorypathway may be involved calls for in-depth biochemical andmolecular biological analyses, currently being undertaken.Studies on the bioavailability of the provitamin A, transfer ofthe trait into agronomically important varieties, and risk assessmentswill be carried out in collaboration with other researchinstitutes.
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