For over one hundred years oxygen has been given to patients presenting with acute cardiac chest pain (Steele, 1900). The rationale is that it will correct the oxygenation imbalance of the ischemic myocardial tissue (Burls et al., 2009). Wijesinghe et al. (2009) supports the theory that oxygen delivery to the ischemic myocardium, reducing the size of the MI, improves patients’ outcomes. However prior to this study, which only involved twenty-seven patients, there have only been two randomised controlled trials (Cabello et al.,2010)