Based on structural effects and signalling processes, PUFA
affect macroscopic properties of the skin essential for
cutaneous health. Supplementation with LA and GLA from
borage oil over a 2-month period leads to decreased transepidermal
water loss (TEWL) and itching. Dry skin appearance
was diminished significantly, but no alteration of skin
hydration was measured(12). LA deficiency results in deformation
or absence of the lamellar bodies, giving way to
water passing the epidermis(13). Consumption of flaxseed oil
rich in ALA or DHA/EPA-rich fish oil is associated with
lower levels of proinflammatory eicosanoids(14). In the present
study we investigated the effects of 12-week oral supplementation
with flaxseed or borage oil on human skin properties.