In most cultivars, phenol and flavonoid contents were 77–121% and 33–74%, respectively higher than those previously reported for the same cultivars grown in Tunisia (Tlili et al., 2011). An exception was represented by Crimson sweet cultivar, in which the amount of total phenols remained almost identical. These differing results are mainly due to environmental and soil conditions, since the applied agronomical techniques were identical. A much higher content of phenols, ranging between 870 and 910 mg GAE kg1 fw, was reported by Perkins-Veazie (2002) in red fleshed watermelon cultivars grown in Oklahoma.