Gives You Hell" was featured on the musical comedy-drama television show Glee in the episode Hell-O. The song was sung by the character Rachel Berry played by Lea Michele.
The song is also featured in the video games Rock Band, Guitar Hero 5, Band Hero and Tap Tap Revenge 2.
The song is also used as into music for the home games of the Missouri Mavericks hockey team in Independence, Missouri. "Gives You Hell" has also been covered by rock band The Inevitable Backlash, with some of the original lyrics slightly altered.