Studies carried out to date reveal NAFLD’s relationship with respiratory diseases such as OSA and COPD due to pathophysiological triggering mechanisms such as obesity, insulin resistance, and systemic inflammation, which predispose individuals to exacerbate these respiratory diseases. On the other hand, its relationship with asthma is not scientifically established; however, knowing NAFLD’s systemic inflammatory component makes it possible to infer its interaction in different organs and body systems. Inflammatory cytokines released due to liver inflammation can interact and affect pathologies with a clear inflammatory component such as asthma; the lack of research on the subject leaves us with an idea without scientific support.