Most individuals living in the region are Hispanic. However, smoking behav- iors are likely to vary in the Hispanic population on either side of the border, given differences in sociodemographic characteristics, access to healthcare, and tobacco policies and prevention and ces- sation programs (9, 12–17). The U.S.– Mexico Border Diabetes Prevention and Control Project survey provides an un- usual opportunity to compare smoking behaviors among Hispanic adults with diabetes in the U.S. and Mexican border populations. A better understanding of smoking behaviors across border sub- groups with diabetes may help to target intervention and allocate resources.