2.2. Mechanisms to detoxify lipid electrophiles in vivo
The extent and severity of cellular damage elicited by electrophiliclipids are highly dependent on the ability of cells to clear and detoxifythese aldehydes. Once formed, the cell attempts to clear electrophiles
through mechanisms involving glutathione (GSH), aldehydedehydrogenases, aldo–ketoreductases and P450 enzymes