Andrographis paniculata (AP) has been widely used in Asian countries to treat many kinds of diseases
for several decades. Hutchison Medipharma Ltd. developed an aqueous ethanol extract of
A. paniculata (APE) named as HMPL-004 to treat inflammatory bowel diseases. The representative
chemical components of HMPL-004 include andrographolide (AND), neoandrographolide (NAND),
14-deoxyandrographolide