Although SUBRAMANIAN et al. (2006) reported that the most possible wound healing
explanation of this extract is that Av increases wound healing by stimulating fibroblasts directly, compared to those of the untreated ones, the fi broblast count of the treated lesions in the present study did not improved significantly. It seems that Av is not effective in the proliferation of fibroblasts but it exerts its effects on the further maturation and alignment of the fibroblasts and collagen fibrils and eventually improves the biomechanical characteristics of the granulation tissue. However, more investigation, especially in vitro,is needed to fully evaluate the effects of Av on fibroblast metabolism and proliferation.