The potential of plants and their associated microorganisms to serve as an environmental counterbalance to industrial pollution has recently been recognized. Although the use of marginal land contaminated with heavy metals for biofuel production can reduce the need to use viable crop land, it is also important to remove contaminants from these sites as biofuel plants are not concerned with food chain contamination. In plants, a rhizosphere zone is a range of processes that induce either directly by the activity of plant roots or by the activity of rhizosphere microflora. Plant rhizospheric secretion of various organic acids, aided by plant-producing chelating agents, pH changes, and redox reactions, are able to solubilize and accumulate at low levels, even from nearly insoluble precipitates. The roots also provide a resourceful habitat for the growth of different types of bacteria (gram negative) and fungi that facilitate growth, nutrition, plant competitiveness, and reducing trace elements toxicity or increasing labile metal pools and uptake by roots. The use of aquatic or terrestrial plants to remove heavy metals from contaminated sites has been extensively tested and studied. There are also many reports on the metal-resistant root-associated beneficial microbes that could improve plant survival in metal-polluted soils and enhance heavy metal extraction by plants.